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- Actifol is an active form of folic acid, which acts as a vital coenzyme for nucleic acid synthesis (the building blocks of DNA and RNA).
- It is used in situations where methotrexate has inhibited the activation of folic acid, such as in cancer treatments or specific health conditions.
- Methotrexate works by blocking folic acid, which can halt nucleic acid synthesis. Leucovorin helps to "rescue" cells by providing folic acid in its active (reduced) form, allowing the synthesis process to continue despite methotrexate's effects.
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✅ Description:
Actifol 15mg Tablet is an important medication used in the management of colorectal cancer, methotrexate toxicity, and folate-deficient megaloblastic anemia. It works by rescuing cells from methotrexate-induced damage, ensuring nucleic acid synthesis proceeds. Care should be taken when using it, especially during pregnancy, breastfeeding, and in patients with certain underlying health conditions. Regular monitoring is essential for safe use.
- Take Folinic Acid exactly as prescribed by your doctor.
- Swallow the tablet with a glass of water. Do not crush or chew the tablet.
- The appropriate dose will depend on your age, body weight, and the medical condition being treated. Your doctor will determine the duration and dosage.
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✔️ Side Effects
Uncommon Side Effects
- Urticaria (hives)
- Dermatitis (skin inflammation)
Serious Side Effects:
- Allergic Reactions: If you experience any of the following symptoms, stop taking the tablet and contact your doctor immediately:
- Swelling of the face, eyelids, lips
- Sudden wheezing or difficulty in breathing
- Rash or itching covering your entire body
✔️ Indications:
- Colorectal Cancer: Used as an adjunct to fluorouracil in chemotherapy for colorectal cancer.
- Methotrexate Toxicity: Used as an antidote to reverse the toxic effects of methotrexate.
- Folate-Deficient Megaloblastic Anaemia: Used to treat anaemia caused by folate deficiency.
✔️
Adult Dose:
Methotrexate Toxicity:
- Oral: 15 mg every 6 hours for 10 doses, starting 24 hours after the methotrexate infusion. Continue until methotrexate serum levels are <0.05 micromolar.
- Intravenous/Intramuscular: Administered as needed depending on the patient's condition.
Folate-Deficient Megaloblastic Anaemia:
- Oral: 15 mg daily.
- Intramuscular/Intravenous: Up to 1 mg/day depending on the severity of the condition.
Adjunct to Fluorouracil in Colorectal Cancer:
- Intravenous: 200 mg/m² BSA (Body Surface Area) by slow IV injection over at least 3 minutes, followed by 370 mg/m² fluorouracil by IV injection.
- Treatment Cycle: Given for 5 consecutive days, repeated at 28-day intervals for 2 courses, and subsequent cycles every 4-5 weeks if the patient recovers from toxic effects.
✔️ Mode of Action:
- Folinic Acid (Calcium Folinate) enters cells as 5-methyl tetrahydrofolate, which supplies the necessary cofactor for nucleotide synthesis, bypassing the blockade caused by methotrexate.
- It stabilizes the binding of 5-dUMP and thymidylate synthetase, which enhances the activity of fluorouracil and counteracts the effects of folic acid antagonists such as methotrexate.
✔️ Drug Interactions:
- Fluorouracil: Folinic acid may increase the toxicity of fluorouracil when used together.
- Sulfamethoxazole-Trimethoprim: Folinic acid may reduce the efficacy of this antibiotic combination in the treatment of Pneumocystis carinii pneumonia, particularly in HIV/AIDS patients.
✔️ Contraindications:
- Hypersensitivity to folinic acid or any other component of the product.
- Pernicious anaemia or other megaloblastic anaemias due to vitamin B12 deficiency.
- Intrathecal or intraventricular administration is not recommended.
✔️ Precautions:
- Undiagnosed megaloblastic anaemia or folate-dependent tumors.
- Pregnancy: Use with caution and only if necessary.
- Regularly monitor calcium levels when receiving combined 5-Fluorouracil/Folinic acid treatment.
- Monitor serum methotrexate levels to adjust the dosage of folinic acid.
- Regular CBC, electrolyte, and liver function tests are recommended during treatment.
✔️ Storage Condition
Do not store above 30°C. Keep away from light and out of the reach of children.
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here information is for informational purposes only.
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